Methods in Molecular Biophysics

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Product Description

Our knowledge of biological macromolecules and their interactions is based on the application of physical methods, ranging from classical thermodynamics to recently developed techniques for the detection and manipulation of single molecules. These methods, which include mass spectrometry, hydrodynamics, microscopy, diffraction and crystallography, electron microscopy, molecular dynamics simulations, and nuclear magnetic resonance, are complementary; each has its specific advantages and limitations. Organised by method, this textbook provides descriptions and examples of applications for the key physical methods in modern biology. It is an invaluable resource for undergraduate and graduate students of molecular biophysics in science and medical schools, as well as research scientists looking for an introduction to techniques beyond their specialty. As appropriate for this interdisciplinary field, the book includes short asides to explain physics aspects to biologists and biology aspects to physicists.

Methods in Molecular Biophysics Review

This is an excellent text in terms of covering the various techniques used in the field. Compared with other similar texts, this one includes mostly everything you'd ever want to know about and goes into good depth on its topics.

That being said, much like other books covering the same subject, this just doesn't feel finished. The book is sometimes brief when it should be explanatory and precise, and its explanations of the science behind the techniques sometimes leave out key logical steps. In its rush to get to complexities in the techniques, it neglects to give concrete examples of the basics. The thermodynamics sub-chapters covering ITC and DSC, for instance, do not spend enough time explaining the basics of how these instruments actually translate their raw data, in the form of graphs, into thermodynamic values. With the relative vacuum of books on these topics, these sorts of things become important - adding a well-labeled diagram and a paragraph or so would not bloat the book too much.

These problems, however, are a common occurrence in textbooks in this field. The competition is not very competitive. In the end, the respectable scope and depth of this book brings it to the front of its rather lackluster pack. Recommended, but I wish there was something better.

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