The Fetal Matrix: Evolution, Development and Disease

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New discoveries reveal how crucial interactions which determine our destiny occur before birth, when our genes interact with their environment as the embryo and fetus develop. These processes -- in the matrix of the womb -- are evolutionary echoes of mechanisms which allowed our hunter-gatherer ancestors to survive. These exciting insights into predictive adaptive responses suggest new ways of protecting the health of the fetus, infant and adult. If inappropriate they can trigger obesity, diabetes and heart disease, formerly thought to result solely from adult lifestyle. The new concepts in this book are crucial to understanding the daunting public health burden in societies undergoing rapid transition from poverty to affluence. They add an important new dimension to evolutionary theory. Synthesising developmental biology, evolutionary history, medical science, public health and social policy, this is a ground-breaking and fascinating account by two of the world's leading pioneers in this important emerging field.

The Fetal Matrix: Evolution, Development and Disease Review

The Fetal Matrix is a lucid, detailed and comprehensive account of the fetal environment's effects on health, disease and mortality in the middle and later years of the human life cycle. It is the product of years of fertile research collaboration between its distinguished authors. Professor Peter D. Gluckman is University Distinguished Professor and Director, National Research Centre for Growth and Development, University of Auckland and a foreign member of the Institute of Medicine, National Academy of Sciences (USA). Professor Mark Hanson is Director, The Centre for Fetal Origins of Adult Disease, Southampton University and a fellow of the Royal Society of Medicine (UK). The book is intended for a broad readership that includes researchers in developmental and evolutionary biology, prenatal medicine, epidemiology, health policy and educated lay people.

Professors Gluckman and Hanson follow up on the path-breaking epidemiological work of Professor David Barker (Mothers, Babies and Health in Later Life), which caused a major stir in medical and public health circles by indicating that disease causes were not exclusively or primarily the result of simplified genetic "traits" or life-style factors. Events unfolding in utero were an essential part of the story. In Chapter One, Gluckman and Hanson provide a nice primer for understanding gene regulation in response to environmental signals. For a more detailed exposition the reader might want to read Matt Ridley's Nature Via Nurture, and, though more technical, Massimo Pigliucci's Phenotypic Plasticity, Mary Jane West-Eberhard's monumental and prize-winning Developmental Plasticity And Evolution and A. R. Cellura's The Genomic Environment And Niche-Experience. In Chapter Two, the authors present a wealth of information from their specialties in embryological and fetal physiology and prenatal medicine, which for the non-specialist will likely be worth the price of the book. (Incidentally, each chapter stands on its own so readers can pick and chose according to their interests.) Chapters Three, Seven and Eight contain a detailed exposition of the authors' concept of the "predictive adaptive response" through which they integrate concepts from genetics, fetal physiology, the extra-uterine environment and evolutionary theory. In Chapters Five and Six specific connections are made between in utero genetic switching, the extra-uterine environment and diseases that often emerge in later life such as cardiovascular disease and diabetes. Chapters Nine and Ten focus on the health policy implications of the authors' findings.

The Fetal Matrix is well written with many interesting examples provided to illuminate key points of the authors' thesis. An excellent index is provided and a bibliography from the scientific literature of almost 500 citations. I recommend it highly as a contribution to the rapidly growing literature on developmental plasticity, genomic regulation and human physiological adaptive processes.

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The Geography of Developing Areas

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This significant new textbook questions traditional conceptions of Africa, Asia, Latin America, and the Caribbean to provide a new understanding of the ��Global South � , highlighting the rich diversity of regions that are usually only viewed in terms of their ��problems� �. Providing a positive but critical approach to a number of key issues affecting these important areas, the book:

• examines the ways in which the Global South is represented, and the values at play


• explores how the �South is shaping, and being shaped by, global economic, political and cultural processes


• looks at peoples� � lives and identities


• assesses the possibilities and limitations of different � development �� strategies.

A timely assessment of the way global processes are perceived from the Global South, the book is illustrated with over� sixty colour photographs. It includes a full glossary of key terms, case studies from fieldwork conducted across a range of communities and nations, and introductions to the wider literature in this field.

This is a wonderful new textbook for all students interested in Human Geography and Development Studies.

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The Geography of Developing Areas Review

The book arrived in just a few days and was in great condition (I bought it new).
I ended up not needing the book and so I had to return it. Return process was very easy and hassle-free! I got my refund within a few days.
I'll use this seller again in the future, for sure.

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The IACUC Handbook

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Ever since its establishment by USDA regulation in the mid-1980s, the Institutional Animal Care and Use Committee has evolved as the premier instrument of animal welfare oversight within research institutions in the U.S. Its mission, in part, is to ensure that investigators, research technicians, animal care personnel and others are adequately trained to conduct research with animals in a proper and humane manner. But equally important is that the IACUC itself be adequately trained with regard to the successful interpretation and implementation of regulations and guidelines for proper animal care and use.

The IACUC Handbook focuses on both basic and advanced concerns of those who participate in activities of Institutional Animal Care and Use Committees. Exhaustive in its content and written by leading authorities in the field, this handbook addresses those questions and problems that often confront IACUCs, and gives accurate, succinct answers. Information is provided in "Question and Answer" format, with the authors offering their personal opinions against a background of regulatory information.

Under the "regulatory " heading, pertinent sections from such sources as the Animal Welfare Act and its regulations, the Health Research Extension Act of 1985, the Public Health Service Policy on Humane Care and Use of Laboratory Animals, the Guide for the Care and Use of Laboratory Animals, and others are included. The handbook also provides the personal opinions of chapter authors and results from informal surveys as examples of the approaches institutions have taken to solve complex issues. While not scientific, the surveys provide the reader with additional opinions.

With the role and impact of the Institutional Animal Care and Use Committee expected to grow in scope and complexity, The IACUC Handbook provides a foundation for those attempting to understand and implement the many and varied responsibilities of this committee.

The IACUC Handbook Review

This Handbook is a must-have reference for any IACUC office. I found clear, intelligent answers to my questions about every elkement of IACUC involvement. I highly recommend this resource. It is by far the most used IACUC resource I have.

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Language, Cognition, and the Brain: Insights From Sign Language Research

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Once signed languages are recognized as natural human languages, a world of exploration opens up. Signed languages provide a powerful tool for investigating the nature of human language and language processing, the relation between cognition and language, and the neural organization of language. The value of sign languages lies in their modality. Specifically, for perception, signed languages depend upon high-level vision and motion processing systems, and for production, they require the integration of motor systems involving the hands and face. These facts raise many questions: What impact does this different biological base have for grammatical systems? For online language processing? For the acquisition of language? How does it affect nonlinguistic cognitive structures and processing? Are the same neural systems involved?

These are some of the questions that this book aims at addressing. The answers provide insight into what constrains grammatical form, language processing, linguistic working memory, and hemispheric specialization for language. The study of signed languages allows researchers to address questions about the nature of linguistic and cognitive systems that otherwise could not be easily addressed.

Language, Cognition, and the Brain: Insights From Sign Language Research Review

The book doesn't seem to be intended for a lay readership as it purports to be. Instead,it's fairly technical in terminology and statistics. For a better understanding of it,get yourself prepared in the basic knowledge of linguistic structure and psycholinguistics.

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Model-Driven Architecture in Practice: A Software Production Environment Based on Conceptual Modeling

You looking to find the "Model-Driven Architecture in Practice: A Software Production Environment Based on Conceptual Modeling" Good news! You can purchase Model-Driven Architecture in Practice: A Software Production Environment Based on Conceptual Modeling with secure price and compare to view update price on this product. And deals on this product is available only for limited time.

   

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This book introduces all the relevant information required to understand and put Model Driven Architecture (MDA) into industrial practice. It clearly explains which conceptual primitives should be present in a system specification, how to use UML to properly represent this subset of basic conceptual constructs, how to identify just those diagrams and modeling constructs that are actually required to create a meaningful conceptual schema, and how to accomplish the transformation process between the problem space and the solution space. The approach is fully supported by commercially available tools.

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Model-Driven Architecture in Practice: A Software Production Environment Based on Conceptual Modeling Review

This book was packed with information. The authors call their approach the OO-Method and the first part of 50 pages puts the OO-Method into its historical perspective and in true scholarly fashion gives credit to others where credit is due. If you have been around for a few years you can probably lightly gaze over this section.
The second part of almost 200 pages is called "Conceptual Modelling: About the Problem Space" and documents what you capture to build an object model, dynamic model, functional model and presentation model. It also covered both green-field and legacy systems modeling which I found enlightening.
It seems to be very complete and somehow has the feel of an undergraduate course rather than a book for experienced professionals. While the descriptions are good, I found many of the worked examples trivial and verbose.
The visual style is also a little dense with almost no diagrams in the book, no colour, no fancy fonts (except for the examples which are in italic and thus easily skipped).
The third section of almost 100 pages called "Conceptual Model Compilation: from the Problem Space to the Solution Space" is an interesting discussion on how you delivery a working piece of software once you have captured the problem using the OO-Method and includes mention of their own commercial OLIVANOVA tool as well as a comparison to OMG's MDA approach.
My first read of this book was cover to cover and in general had me nodding rather than scowling. I have been back in with the highlighter to lift the gems and I'm sure I will be reading various chapter again to refresh my memory for upcoming projects.
Thanks guys for an excellent book. Not a casual read but definitely worth the effort.

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