Practical Synthetic Organic Chemistry: Reactions, Principles, and Techniques

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Product Description

A hands-on guide to assist in the planning and execution of synthetic reactions in the laboratory

Despite the maturity of organic chemistry, it can still be very challenging to identify optimal methods for synthetic transformations that perform as well in real-world manufacturing processes as they do in the laboratory. This detailed and accessible guide attempts to address this vexing issue and deliver proven methodologies practicing synthetic chemists will find valuable for identifying reaction conditions that work reliably over the broadest possible range of substrates.

Practical Synthetic Organic Chemistry:

• Provides a practical guide to strategically planning and executing chemical syntheses for the bench chemist in industry

• Discusses information that is not common knowledge beyond the boundaries of process chemistry groups, such as the synthetic routes of selected contemporary pharmaceutical drugs and practical solvents, as well as green chemistry concepts

• Highlights key reactions, including substitutions, additions, eliminations, rearrangements, oxidations, and reductions

• Addresses basic principles, mechanisms, advantages and disadvantages of the methodology, and techniques for achieving laboratory success

Incorporating such an extraordinary wealth of information on organic chemistry and its related fields into one complete volume distinguishes Practical Synthetic Organic Chemistry as an incomparable desktop reference for professionals� and an invaluable study aid for students.

Practical Synthetic Organic Chemistry: Reactions, Principles, and Techniques Review

Practical Organic Chemistry is a superb collection of modern organic transformations (chapters 1-13) and useful associated information at the end (chapters 14-20). The synthesis chapters are broken down into general reaction classes and further separated into reaction subclasses or strategies. This level of organization puts the emphasis on informative examples rather than on a laundry list of reagents. In this regard, the text resembles Carey & Sundberg Part B, but with a crisper, more concise and more updated appearance. In addition, POC is also about 100 pages shorter and, as a result, easier to consult. Later chapters include useful topics such as "Access to Chirality", which summarizes chiral pool, catalysis, resolution etc, "Green Chemistry", which features guiding principles and specific examples and "Naming Carbocycles & Heterocycles", which is a nice summary of various cyclic organic architectures with both IUPAC and the more generally useful common names. A particularly notable chapter is 18 "pKA", which contains a discussion and comprehensive tabulation of the acidities of organic molecules. This type of summary, which has circulated among organic chemistry grad students and postdocs for decades, is more complete and useful than ever, given the central role of pKas for comparing electron-withdrawing capacity, anion stability, and a host of other effects that are useful for troubleshooting and designing synthetic pathways. And I have to mention chapter 15 "Synthetic Route Development of Selected Comtemporary Pharmaceutical Drugs", which provides concise summaries of initial medicinal chemistry routes the are evolved into large scale processes...this is extremely useful information that would be difficult to pull from the primary literature. Similar information is found in "The Art of Drug Synthesis"(Johnson and Li), though not necessarily with the specific emphasis on multiple routes to the same target.

In short, this useful compendium is perfect for anyone close to the lab...I will be purchasing copies for my academic labs and I expect that it will also prove useful for organic chemists in pharmaceutical and related industries.

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